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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cd61fe294475a74b02f3fd37301dc8270b8efbb706069855f5004c0793546a57' 
  AND token = 'n1WJHtSCuyA6V9oma5qgGBmvoBthq4JjFAA5a+yCyJM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}