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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'da378ec28ea5294c307787def3e7de4023d06bad2b6c6ff924318dc4231abf34' 
  AND token = '3VrnA35abIU25DHmFGuebRmy9gi2SpRXMT5Qh+65UpQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}