SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6e3f71862271feeccf124967a25797624dd7ff233fb6f5c816f69017f5ac71d9' 
  AND token = '5anRvW8IaoIFDvUMDAOLYXW4OWvxe1XZy1wom1ORryI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}