SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e9581df9efca99f772ee607f32d5464df1ca053465609ab43002c73f72f28080' 
  AND token = 'TXi3uunE+PoivynAAuqAaAGBOgvNqf2NIftuzb5bK4A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}