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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '455874ea7fd75763efac01751a8ebdc4dc60fce685df2b1708a6e97864101eb4' 
  AND token = 'I82e2RcFMzu/SZ/CFGKwYEHntoBYr2AZz6jYqFX1e0A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}