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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6341121d09b10ab62d6aad9e9ca0a45605bfbb6c9c51cedeae378e4d39cff013' 
  AND token = 'oMeh+oAvU0QvmLvjaq4kjlB9yLB+Z61HQX3FQ1ci0I8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}