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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7a221245214fe84fbaa20c31dc30d1fe7c6df4c1c337b3b536aef4b70efe0267' 
  AND token = '/VZlgZs7o6xfKiRFMZIEbF38LEpGoG0CM2M9Z4mvNFc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}