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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '44ed2108a032c305227a121151949154c0bd1a065cd149b592dc7bc468e00248' 
  AND token = 'qkkjjDKPfkGa38yhPbXlOWkieaIf0C+PF9ViCJIZxi8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}