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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52f7b63cd2c1486d5fd97d16b2906a4b00303b4a7b5ea8c06879309e64202845' 
  AND token = 'W+AcLT/iIx2KP3M5eV8u08fQ2nQZZuMCX6d7vkLMjRc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}