SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '220cb5b26b436434c46a78f9a3330b67f81cae6ba2a014bdc08e71cf91a9900b' 
  AND token = 'RQYCV7Baq/LpLD07jSrZKC3L3xYdwVSCeBrlyEf+Zl8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00040

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}