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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2206fe4de8309b3f493ef4b428309a221b292260d587e112f58c7b84f9edfb87' 
  AND token = 'C2AqCdTk5Hq2PpcFRiKnFoXU2VXYdlbRH4pbCCk2cNY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}