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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21b4042c19bb9f2a14918e3496adb50effdf4d90a7c5955f337ba5c3c6165667' 
  AND token = 'UsRCziRKRZdfByZhT9GHW6mBpHFZSa0imZFKpTRHzKM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00014

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}