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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0b4eefb5c36e59c056cc1c1b44d7e5e05746e22c737f18f09e2219bd36456527' 
  AND token = 'ASC5USVOQGa0z3Vjx2UrGknFftVNtzA758GMMZkKWA8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}