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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f4725ad68f132d9e2550336966fc6b255fdc756785972d910c76f34c9f01f2b5' 
  AND token = 'As5g8HOF56O+I6yFwjILsPR5I+oGvDDQTnhWz58XuKg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}