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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1221deb6afb3262db87f2a35b7bbe953692a85bc466c9f4f2709ae66b378d038' 
  AND token = 'BcH6rTsrsCGrRzLReKozWjV2t+EKEfMWIPjDlQ7tW3g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}