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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1b53efe93db25515b0532e7d1733cc7142ba4a62b7b94b1f5337e53a4b0dcc86' 
  AND token = 'wQK0mfdbykmxJhDI0Uj5ED+3s/UJAGYgajPIi25R5Rc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}