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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21a9ade569c460d4e1453a5e6efe38d6443b873714e01151786f95bf5eec0204' 
  AND token = 'Owwd0O+N22d6Lc2xM5qzZqhaYHpbb61KYW4xaQO1beQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}