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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a812b09cd70a026f3e8c130ec04b69911d33e783260b1e2892ee032ccc9c8c83' 
  AND token = '2IjlW74p7qxqeY9XCko06oX3vVRmvf1di+hPlxwbbKE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}