SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e2a00017f6707bc591861a62f0b0c1d099f2064f2b1ea73f8bba23766a562537' 
  AND token = 'IUoJDMbh4waZFn/Mnsio+0fzEPredbWuZE3k9c2gxf4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}