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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '44188e894aafda2a9fd16525aa26f32c6e8a6477eb8ebc6e12e36083fcac1e91' 
  AND token = 'MxiQqcOhLzHSWWXreFXiO5jcB8BktsvuXQ8ONA5o0V0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}