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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c85e8042925e19ffb68f47e082acb81a8b5e2a4c09ba6ee426022376b47d7203' 
  AND token = 'uR1+qrdMwe6JwoAsbE8y5V4ePc1hTjq5j+MpAjPTsw4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}