SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c4d024296c22f49073f6d14271afc85dc222b094dff8c013620336dfe31024e0' 
  AND token = 'HdeJsAPOjemlymgiQ0MNkN5/nM4G3fZJZWKFwu4WZY8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}