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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e45cade421ddd45831b95fc3837f50abe6f9c15edcf16e281f19cf1827d30b7' 
  AND token = 'cTh2XtX4Fl4cTuuWli4NZI+ksL7KcL2mnAaip/WrvUY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}