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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '44b2f25746170aa3b81fb05e058d37017b2e2ffbe42e1542c182edf68d04b276' 
  AND token = 'vUWcf+a5kb/JA2RUXLtXqsBYHW2/4LYoQoMO2X4eVXM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}