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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c8acb4544429ca8e368510da9c09fe007cb43e5d3a6f3f1f1d3a1151291192af' 
  AND token = 'OPcBFrVUlolkajm+j5QaWBElPOpJM31LeW8ZXst/9xc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}