SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e117e0d4048db0f03ea031bb2a308f60fcfe5e42c2efce9287f65db84d606595' 
  AND token = '2z2qGtZXdO6OxNA0UYIOuqF+kjB1PWQFFizHUTBpXvU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}