SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '33a3aaef4e81ff2bfd5644bc49c2a2c5441900538a956ce3f73ddfde2e687025' 
  AND token = 'eIemnqGKI+OzWRPJ/BSYO1V7EIOcCrxcqbTcUUzqnDA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}