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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd6006cee66fae63be3d90f4350f949e5aad39546c06d8e2bc004f863e060fb1f' 
  AND token = 'WPTM05SLxHot/RVxwyYZ/nuTLo7Zlh3C8aaJ37mM1Uk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}