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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '56dfd3221aa1b244b49c63c42b5730d8c4b428c5e1f48495c8d7f373d3973b36' 
  AND token = 'wA0QGaxNDo1AZtDAVOKYYRAj/SfNMZvjQF6ENyU3QiM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}