SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22f4346b859f5a8f1ca362cbdd65eb3d305ab1622612a2f40926edc402e75f13' 
  AND token = '+XKLfippXnMhpmrD9rUm1CDutJay7kZM84ptwiKxceA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}