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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49af0b4d238660c6943dfa66a416c7a41584e29c26e9bb14fdc790c5aa247c97' 
  AND token = 'dTQ/VZrBhEhWlOFRFVLjE5tp75zf3c7QIUoNZb3n9AA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}