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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a334a6259528708df92d4d8640b10790626dc3f7aae905c3fd540575112c8fe9' 
  AND token = 'EPACcNGpLx3e5YiWYZzrWZbxWRq0cvebVfgvDRQrTy8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}