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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '57dc6f320e772d2387f35833e7a9b175c3964a22ec9056fece4cc9a44f842dc6' 
  AND token = 'Rsru6QoQxNO3Re4Xiif7D9sZJeT2lyXSV1JdohcfuTc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00012

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}