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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '59373d05b246a3558dee30df6b7c59711e588aefd4fb7de4d43b470e1dcfab5c' 
  AND token = 'ye3aFYKaCvsxkqQaPsVjOcVP9fWXd5b0jrMZqoRiOE0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}