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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0f8858ea1226f8c235f3aa5eb6384ccd5302ce525a2d4f11f3871f9c3f30198c' 
  AND token = 'B8ubm0wmUIuvHbBjWft+1RbOXNq4GXVS/3G0VEfNbYc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}