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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52509be271bbb605173cf06422717cc2f4fcd5ce541a3670cfadb77cff9efaf1' 
  AND token = 'GeDAs81n6k53dl+/p/f9X0JlwLyNWM43pjd3AsJ8ZnA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}