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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0435e5a21d6fe022e88e29931afa2f03ea18a3a41c7b853e209bebe90c8a40f0' 
  AND token = 'ezt1UoERfppopFKAoubx7u6+LPaGHJVT++fd/ot4Yz4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}