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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53282b7e7e914403a27b148d91a75f4d7648aaaab4440ff5a1125cb0a0a49149' 
  AND token = 'SxzHEF6+Emp8NGX49+8fNJwSM/BItR/RrlJEQJBzLHA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}