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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43c3bf69f09fe8924e73ca0711ad7f46521f39d9667a9c98f9a3aefe3f978380' 
  AND token = 'UwllHTMASUvk+QMm+hgMVpY3ll01xgV0YToraGqKumM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}