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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81b82921497dd4d80c5c0710eea78d0c48480851cb5c91455dc195571d7339c1' 
  AND token = 'H2GsxGQ69yV2aX+XCLvjLh6gEBikAg5cPs1VHnX7DL0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}