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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8f221a51f3af5d6ae661cae0b4bc37c058c0d00608b489930a8a8186d2b7fd8f' 
  AND token = 'mi8hH6bXv+uXx56sG2oDXhl7yOIHyxlUYftNtoKCglI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}