SELECT 
  cscart_bm_layouts.* 
FROM 
  cscart_bm_layouts 
WHERE 
  1 
  AND is_default = 1 
  AND theme_name = 'aquawagon' 
  AND storefront_id = 3

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "cost_info": {
      "query_cost": "2.10"
    },
    "table": {
      "table_name": "cscart_bm_layouts",
      "access_type": "ref",
      "possible_keys": [
        "is_default"
      ],
      "key": "is_default",
      "used_key_parts": [
        "is_default",
        "storefront_id"
      ],
      "key_length": "5",
      "ref": [
        "const",
        "const"
      ],
      "rows_examined_per_scan": 6,
      "rows_produced_per_join": 0,
      "filtered": "10.00",
      "cost_info": {
        "read_cost": "1.50",
        "eval_cost": "0.06",
        "prefix_cost": "2.10",
        "data_read_per_join": "360"
      },
      "used_columns": [
        "layout_id",
        "name",
        "is_default",
        "width",
        "layout_width",
        "min_width",
        "max_width",
        "theme_name",
        "style_id",
        "storefront_id"
      ],
      "attached_condition": "(`s2cart`.`cscart_bm_layouts`.`theme_name` = 'aquawagon')"
    }
  }
}

Result

layout_id name is_default width layout_width min_width max_width theme_name style_id storefront_id
78 UniTheme 2 (Light v2) - ult9 1 16 fluid 280 1400 Aquawagon Black 3