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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '412aa7c1f8f374ad67022d453fbf7c3f94705e38349a2b4289db9425c6be536d' 
  AND token = 'vSkmCY74+cR4wVM1KrinRTDFWSltyw97ugVsgR274TY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}