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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '750581c86f6ff9326b72f2ca40972e08b70410ee85d789f675e1cd471aca6dd8' 
  AND token = 'UIHkeYDL/nn7MeqgvQkRXGBbXlqZEQ3g0zAQ16gWui8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}