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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de00eebe3ff2124d32425999c5188d8a1d15dac6cdb81c6e7b13c0bb7b7eb438' 
  AND token = 'Uf5ayJNfjlmnXaiYkR+DYsEoo7yd6gkZlrY8nmd7tm4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}