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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3cf150278865a1f27dba67b4581a75b260fe435e21bd75a1d752928b6c3d6e6f' 
  AND token = 'E7gCMI2b+Vp5l9QvBBY7cpjSVOn4m6AorVsC/btih0I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}