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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21c81b3054d9e0fd8c2bf6b961823c02f1ecb97c9aef13452939b9091d1b9801' 
  AND token = 'Fh6FVVv0GgMq/K+tcKAomlIGvVuEI9EiIFD3dJpNesM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}