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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '04ddd221257c98a8457a9ce1bfe21100c57965f47fb8dc90608949c8c878845a' 
  AND token = 'eGyY2O1xaOkH8vunx9DK5rLNj1qWJCTkJnoqBbIfJCw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}