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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cedf327b9732afa48b07997eab8b32e3d265c39d72fafc282b2f03602cc5b378' 
  AND token = 'AVoy3Pktp0Hs3PZesHRajRDB0y/DhSMMiF80oe7V6rw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}