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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e282842dfa5a7a06f7dcaeaf11fe976be2ff2b2283562c08671e73d8c5437aae' 
  AND token = 'HXbdjbS4zMlmdnXqsyv6TkgL9uIL7vU/1A820id7IZA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}